Identifying perturbed or dysregulated pathways is critical to understanding the biological processes that change within an experiment.Previous methods identified important pathways that are significantly enriched among differentially expressed genes; however, these methods cannot account for small, coordinated changes in gene expression that amass
Intracerebral hemorrhage (ICH) is a Cart Accessories highly fatal disease with mortality rate of approximately 50%.Oxidative stress (OS) is a prominent cause of brain injury in ICH.Important sources of reactive oxygen species after hemorrhage are mitochondria dysfunction, degradated products of erythrocytes, excitotoxic glutamate, activated microgl
Rheumatoid diseases, including rheumatoid arthritis, osteoarthritis, and fibromyalgia, are characterized by progressive inflammation in the musculoskeletal system, predominantly affecting the joints and leading to cartilage and bone damage.The resulting pain and ongoing degradation of the musculoskeletal system contribute to reduced physical activi
Abstract Training a machine learning algorithm on a class-imbalanced dataset can be a difficult task, a process that could prove even more challenging under conditions of high dimensionality.Feature extraction and data sampling are among the most popular preprocessing techniques.Feature extraction is used to derive a richer set of reduced dataset f